MATERIAL SAFETY DATA SHEET

INDOLE-3-CARBINOL

1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION:

Product Name: Indole-3-carbinol
CAS#: 700-06-1
Synonym: Indole-3-methanol; 3-Indolemethanol; 1H-Indole-3-methanol
Chemical Name: Indole-3-carbinol
Chemical Formula: C9-H9-N-O

2. COMPOSITION AND INFORMATION ON INGREDIENTS:

Composition:
Name CAS # % by Weight
Indole-3-carbinol 700-06-1 100
Toxicological Data on Ingredients: Not applicable.

3. HAZARDS IDENTIFICATION

Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.

4. FIRST AID MEASURES:

Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Skin Contact:
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin Contact: Not available.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Serious Inhalation: Not available.
Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.
Serious Ingestion: Not available.

5. FIRE AND EXPLOSION DATA:

Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of open flames and sparks.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam.
Do not use water jet.
Special Remarks on Fire Hazards: When heated to decomposition it emits toxic fumes (CO, CO2, NOx)
Special Remarks on Explosion Hazards: Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust explosion hazard.

6. ACCIDENTAL RELEASE MEASURES:

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

7. HANDLING AND STORAGE:

Precautions: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Keep away from incompatibles such as oxidizing agents, reducing agents, acids, alkalis.
Storage: Sensitive to light. Store in light-resistant containers. Keep container tightly closed. Keep container in a cool, we l l-ventilated area. Do not store above 24 °C (75.2 °F). Preferably refrigerate.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION:

Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
Exposure Limits: Not available.

9. PHYSICAL AND CHEMICAL PROPERTIES:

Physical state and appearance: Solid. (Powdered solid.)
Odor: Disagreeable
Taste: Not available.
Molecular Weight: 147.18 g/mole
Color: Off-white.
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: 94°C (201.2°F) - 99 C
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water.
Solubility: Partially soluble in cold water.

10. STABILITY AND REACTIVITY DATA:

Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Excessive heat, dust generation, light, incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, acids, alkalis.
Corrosivity: Not available.
Special Remarks on Reactivity: Sensitive to light.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
11. TOXICOLOGICAL INFORMATION:

Routes of Entry: Inhalation. Ingestion.
Toxicity to Animals:
LD50: Not available.
LC50: Not available.
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects based on animal test data
Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects:
Skin: May cause skin irritation.
Eyes: Can cause eye irritation.
Inhalation: May cause respiratory tract irritation. Breathing in small amounts of this material during normal industrial handling is not likely to cause harmful effects. Breathing in large amounts may be harmful.
Ingestion: Ingestion of small amounts during normal industrial handling is not likely to cause harmful effects.
Swallowing large amounts may be harmful. It may cause digestive tract irritation. Symptoms may include mouth and throat irritation, and stomach or intestinal upset (nausea, vomiting, and diarrhea). It may affect behavior/central nervous system (central nervous system depression - dizziness, drowsiness, weakness, fatigue, headache, unconsciousness), metabolism (weight loss), and liver.

12. ECOLOGICAL INFORMATION:

Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation: Possibly hazardous short term degradation products are not likely.
However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.

13. DISPOSAL CONSIDERATIONS:

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

14. TRANSPORT INFORMATION:

DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special Provisions for Transport: Not applicable.

15. OTHER REGULATORY INFORMATION:

Federal and State Regulations: No products were found.
Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada): Not controlled under WHMIS (Canada).
DSCL(EEC):
This product is not classified according to the EU regulations.
S24/25- Avoid contact with skin and eyes.
HMIS (U.S.A.):
Health Hazard: 1
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 0
Reactivity: 0
Specific hazard:
Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.