MATERIAL SAFETY DATA SHEET
Aspartame
1. PRODUCT IDENTIFICATION: Aspartame, NF(NutraSweet)
CAS NO: 22839-47-0
Product name: L- Phenylalanine, N-L-a-aspartyl-, l-methyl-ester.
Chemical name: C14H18N2O5
Uses: Sweetener
2. TOXICOLOGICAL IDENTIFICATION:
Irritancy: May cause eye and skin irritation.
Adverse effects: Slightly hazardous in case of skin contact
(irritant, permeator) of ingestion, of inhalation.
Reproductive Effects Data: Oral
Rat: 275g/kg; Effects on newborn: behavioral
Rat: 106g/kg; Effects on newborn: Growth statistics (e.g. reduced
weight grain).
Rat: 449g/kg; Effects on newborn: weaning or lactation index
(e.g., alive at
weaning per # alive at day 4).
Mouse: 4mg/kg; Effects on newborn: behavioral
Guinea pig: 32500mg/kg; Effects on newborn: behavioral
Toxicity Data: Oral
Rat: LD50:>10000mg/kg
Mouse:
LD50:>10000mg/kg
Intraperitoneal Rat:
LD50:>5mg/kg Mouse:
LD50:>5mg/kg
3. PHYSICAL DATA:
State: Liquid SolidXGas
Description: White, odorless crystalline powder
Solubility: Sparingly soluble in water, slightly soluble in
alcohol.
Other Physical Properties: mw: 294.30 mp: 246-247DC
NF Specifications:
-
Identification<197M>: Positive
Transmittance: <=0.022
Specification<781S>: 14.5to16.5DC
Loss ondrying<731>: <=4.5%
Residue on ignition<281>: <=0.2%
Heavy metals<231>: <=0.001%
Organic Volatile IMP <467>: Meet the requirements
Assay
5-Benzyl-3, 6-dioxo-2-piperazineacetic acid: <=1.5%
Chromatographic purity: <=2.0%
Package and storage: Preserve in well closed containers.
Flammability: May be combustible at high temperature.
5. REACTIVITY DATA:
Stability: Stable
Hazardous Decomp. Products: Carbon monoxide, Carbon dioxide, Nitrogen oxide.
Hazardous Polymerization: Will not occur.
6. PREVENTIVE MEASURES:
Personal Protective Equipment: Safety glasses, lab coat, dust respirator. Be sure to use an approved/certified respirator or equivalent gloves.
Specific Engineering Controls: Use Process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below exposure limit.
Spills & Leaks: Use appropriate tools to put the spoiled solid in a convenient waste disposal container. Finish cleaning by spreading water on contaminated surface and dispose of according to local and regional authority requirements.
Waste Disposal: Recycle to process, if possible. Consult your local or regional authorities.
Storage: Preserve in well closed containers.
7. FIRST AID MEASURES:
Eyes: Check for and remove any contact lenses. Flush eyes with plenty of water for at least 15minutes.
Skin: Wash with soap and water. Cover the irritated skin with an emollient.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult give oxygen.
NOTE: If victim is unconscious, never induce vomiting nor five liquids. Place victim in a stable side position and keep warm.
Ecological Date: N/A
Hazardous Ingredients: N/A
References: Available on request