MATERIAL SAFETY DATA SHEET

L-LEUCINE

1. CHEMICAL PRODUCT IDENTIFICATION

PRODUCT NAME: L-Leucine
CAS#: 61 -90-5
RTECS: OH2850000
TSCA: TSCA 8(b)
INVENTORY: L-Leucine
CI#: Not available.
SYNONYM: 2-Amino-4-methylvaleric acid
CHEMICAL FORMULA: C6H13NO2

2. COMPOSITION AND INFORMATION ON INGREDIENTS

COMPOSITION:
                  Name {L-}Leucine
                  CAS # 61-90-5
                  % by Weight 100
TOXICOLOGICAL DATA ON INGREDIENTS: L-Leucine
LD50: Not available.
LC50: Not available.

3. HAZARDS IDENTIFICATION

POTENTIAL ACUTE HEALTH EFFECTS: Extremely hazardous in case of eye contact (irritant), of inhalation. Very hazardous in case of ingestion.
Inflammation of the eye is characterized by redness, watering, and itching.
POTENTIAL CHRONIC HEALTH EFFECTS: Extremely hazardous in case of eye contact (irritant), of inhalation. Very hazardous in case of ingestion.
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.

4. FIRST AID MEASURES

EYE CONTACT: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
SKIN CONTACT: No known effect on skin contact, rinse with water for a few minutes.
SERIOUS SKIN CONTACT: Not available.
INHALATION: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
SERIOUS INHALATION: Not available.
INGESTION: Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
SERIOUS INGESTION: Not available.

5. FIRE AND EXPLOSION DATA

FLAMMABILITY OF THE PRODUCT: May be combustible at high temperature.
AUTO-IGNITION TEMPERATURE: Not available.
FLASH POINTS: Not available.
FLAMMABLE LIMITS: Not available.
PRODUCTS OF COMBUSTION: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
FIRE HAZARDS IN PRESENCE OF VARIOUS SUBSTANCES: Not available.
EXPLOSION HAZARDS IN PRESENCE OF VARIOUS SUBSTANCES:
RISKS OF EXPLOSION OF THE PRODUCT IN PRESENCE OF MECHANICAL IMPACT: Not available.
RISKS OF EXPLOSION OF THE PRODUCT IN PRESENCE OF STATIC DISCHARGE: Not available.
FIRE FIGHTING MEDIA AND INSTRUCTIONS:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
SPECIAL REMARKS ON FIRE HAZARDS: Not available.
SPECIAL REMARKS ON EXPLOSION HAZARDS: Not available.

6. ACCIDENTAL RELEASE MEASURES

SMALL SPILL: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
LARGE SPILL: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow evacuating through the sanitary system.

7. HANDLING AND STORAGE

PRECAUTIONS: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with eyes In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label when possible.
STORAGE: Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

ENGINEERING CONTROLS: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
PERSONAL PROTECTION: Splash goggles. Lab coat.
PERSONAL PROTECTION IN CASE OF A LARGE SPILL: Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
EXPOSURE LIMITS: Not available.

9. PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE AND APPEARANCE: Solid.
ODOR: Not available.
TASTE: Not available.
MOLECULAR WEIGHT: 131.17 g/mole
COLOR: Not available.
PH (1% soln/water): Not available.
BOILING POINT: Not available.
MELTING POINT: Sublimes. (144°C or 291.2°F)
CRITICAL TEMPERATURE: Not available.
SPECIFIC GRAVITY: 1.293 (Water = 1)
VAPOR PRESSURE: Not applicable.
VAPOR DENSITY: Not available.
VOLATILITY: Not available.
ODOR THRESHOLD: Not available.
WATER/OIL DIST. COEFF.: Not available.
IONICITY (in Water): Not available.
DISPERSION PROPERTIES: See solubility in water.
SOLUBILITY: Soluble in cold water.

10. STABILITY AND REACTIVITY DATA

STABILITY: The product is stable.
INSTABILITY TEMPERATURE: Not available.
CONDITIONS Of INSTABILITY: Not available.
INCOMPATIBILITY WITH VARIOUS SUBSTANCES: Not available.
CORROSIVITY: Non-corrosive in presence of glass.
SPECIAL REMARKS ON REACTIVITY: Not available.
SPECIAL REMARKS ON CORROSIVITY: Not available.
POLYMERIZATION: No.

11. TOXICOLOGICAL INFORMATION

ROUTES OF ENTRY: Eye contact.
Inhalation.
Ingestion.
TOXICITY TO ANIMALS:
LD50: Not available.
LC50: Not available.


CHRONIC EFFECTS ON HUMANS: Not available.
OTHER TOXIC EFFECTS ON HUMANS: Extremely hazardous in case of inhalation. Very hazardous in case of ingestion.
SPECIAL REMARKS ON TOXICITY TO ANIMALS: Not available.
SPECIAL REMARKS ON CHRONIC EFFECTS ON HUMANS: Passes through the placental barrier in animal.
SPECIAL REMARKS ON OTHER TOXIC EFFECTS ON HUMANS: Nuisance dust.

12. ECOLOGICAL INFORMATION

ECOTOXICITY: Not available.
BOD5 and COD: Not available.
PRODUCTS OF BIODEGRADATION: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
TOXICITY OF THE PRODUCTS OF BIODEGRADATION: The products of degradation are more toxic.
SPECIAL REMARKS ON THE PRODUCTS OF BIODEGRADATION: Not available.

13. DISPOSAL CONSIDERATIONS

WASTE DISPOSAL

14. TRANSPORT INFORMATION

DOT CLASSIFICATION: Not a DOT controlled material (United States).
IDENTIFICATION: Not applicable.
SPECIAL PROVISIONS FOR TRANSPORT: Not applicable.

15. OTHER REGULATORY INFORMATION

FEDERAL AND STATE REGULATIONS: TSCA 8(b) inventory: L-Leucine
OTHER REGULATIONS: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
OTHER CLASSIFICATIONS:
WHMIS (CANADA): CLASS D-2B: Material causing other toxic effects (TOXIC).
DSCL (EEC): R41 - Risk of serious damage to eyes.

HMIS (U.S.A.):
HEALTH HAZARD: 3
FIRE HAZARD: 1
REACTIVITY: 0
PERSONAL PROTECTION: j
NATIONAL FIRE PROTECTION ASSOCIATION (U.S.A.):
HEALTH: 3
FLAMMABILITY: 1
REACTIVITY: 0
SPECIFIC HAZARD:
PROTECTIVE EQUIPMENT: Not applicable.
Lab coat.
Wear appropriate respirator when ventilation is inadequate.
Splash goggles.